Medicine

Semaglutide in patients with over weight or even obesity and persistent kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial

.World Health Association. Weight problems and over weight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (2024 ). Non-Communicable Illness Threat Aspect Collaboration. Worldwide styles in underweight and also being overweight from 1990 to 2022: a pooled evaluation of 3663 population-representative studies along with 222 million kids, teens, and also grownups. Lancet 403, 1027u00e2 $ "1050 (2024 ). Articleu00c2.Google Scholaru00c2.International Trouble Disease Partners. Global, regional, as well as nationwide burden of diabetes from 1990 to 2021, along with estimates of incidence to 2050: a step-by-step evaluation for the Global Concern of Condition Study 2021. Lancet 402, 203u00e2 $ "234 (2023 ). Articleu00c2.Google.com Scholaru00c2.Kovesdy, C. P., Furth, S. L. &amp Zoccali, C &amp Planet Kidney Time Steerage Board. Obesity and also renal condition: concealed consequences of the epidemic. Kidney Int. 91, 260u00e2 $ "262 (2017 ). Garofalo, C. et cetera. A systematic customer review as well as meta-analysis recommends excessive weight forecasts start of severe renal condition in the overall populace. Renal Int. 91, 1224u00e2 $ "1235 (2017 ). Articleu00c2.Google Scholaru00c2.Jiang, Z. et al. Being overweight and also chronic kidney ailment. Am. J. Physiol. Endocrinol. Metab. 324, E24u00e2 $ "E41 (2023 ). Articleu00c2.CASu00c2.Google Scholaru00c2.Hall, J. E., carry out Carmo, J. M., da Silva, A. A., Wang, Z. &amp Venue, M. E. Being overweight, renal disorder and hypertension: mechanistic hyperlinks. Nat. Rev. Nephrol. 15, 367u00e2 $ "385 (2019 ). Articleu00c2.PubMed Centralu00c2.Google Scholaru00c2.Renal Condition: Improving Worldwide Results CKD Work Team. KDIGO 2024 Scientific Practice Rule for the analysis and control of severe renal health condition. Kidney Int. 105, S117u00e2 $ "S314 (2024 ). Articleu00c2.Google.com Scholaru00c2.Kidney Condition: Improving International End Results Diabetes Work Team. KDIGO 2022 Scientific Method Tip for diabetic issues control in chronic kidney illness. Kidney Int. 102, S1u00e2 $ "S127 (2022 ). Articleu00c2.Google Scholaru00c2.Oshima, M. et al. Early adjustment in albuminuria with canagliflozin anticipates renal and cardio results: a post hoc study from the support test. J. Am. Soc. Nephrol. 31, 2925u00e2 $ "2936 (2020 ). Articleu00c2.CASu00c2.PubMed Centralu00c2.Google.com Scholaru00c2.de Zeeuw, D. et cetera. Proteinuria, an intended for renoprotection in individuals with style 2 diabetic nephropathy: lessons from RENAAL. Kidney Int. 65, 2309u00e2 $ "2320 (2004 ). Articleu00c2.Google.com Scholaru00c2.Heerspink, H. J. et cetera. Is actually a decline in albuminuria associated with renal as well as cardio protection? A post hoc evaluation of the elevation test. Diabetes mellitus Obes. Metab. 18, 169u00e2 $ "177 (2016 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Michos, E. D., Bakris, G. L., Rodbard, H. W. &amp Tuttle, K. R. Glucagon-like peptide-1 receptor agonists in diabetic kidney health condition: an evaluation of their renal as well as heart protection. Am. J. Prev. Cardiol. 14, 100502 (2023 ). Articleu00c2.PubMed Centralu00c2.Google Scholaru00c2.Muskiet, M. H. A. et cetera. GLP-1 and also the kidney: from anatomy to pharmacology as well as end results in diabetes mellitus. Nat. Rev. Nephrol. Thirteen, 605u00e2 $ "628 (2017 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Marso, S. P. et cetera. Semaglutide and also cardio end results in patients with type 2 diabetes mellitus. N. Engl. J. Medication. 375, 1834u00e2 $ "1844 (2016 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Lincoff, A. M. et al. Semaglutide and also heart results in being overweight without diabetes mellitus. N. Engl. J. Medication. 389, 2221u00e2 $ "2232 (2023 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Perkovic, V. et cetera. Results of semaglutide on severe kidney disease in clients with type 2 diabetes. N. Engl. J. Med. 391, 109u00e2 $ "121 (2024 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Colhoun, H. M. et cetera. Lasting kidney results of semaglutide in excessive weight and also heart disease in the SELECT trial. Nat. Med. 30, 2058u00e2 $ "2066 (2024 ). Articleu00c2.CASu00c2.PubMed Centralu00c2.Google Scholaru00c2.Heerspink, H. J. L. et cetera. Effects of semaglutide on albuminuria and kidney function in folks with obese or being overweight with or without style 2 diabetes mellitus: preliminary study from the action 1, 2, and 3 tests. Diabetes mellitus Treatment 46, 801u00e2 $ "810 (2023 ). Articleu00c2.CASu00c2.PubMed Centralu00c2.Google.com Scholaru00c2.Witch Doctor, A. M. et cetera. Impact of the glucagon-like peptide-1 receptor agonists semaglutide as well as liraglutide on kidney outcomes in clients with type 2 diabetic issues: pooled analysis of SUSTAIN 6 as well as innovator. Circulation 145, 575u00e2 $ "585 (2022 ). Articleu00c2.CASu00c2.Google Scholaru00c2.Apperloo, E. M. et cetera. Effect of semaglutide on kidney feature around various levels of baseline HbA1c, high blood pressure, body weight and also albuminuria in SUSTAIN 6 as well as PIONEER 6. Nephrol. Dial. Transplant. gfae150 (2024 ). Tuttle, K. R. et cetera. Dulaglutide versus blood insulin glargine in patients with style 2 diabetes and moderate-to-severe persistent kidney disease (AWARD-7): a multicentre, open-label, randomised trial. Lancet Diabetes Endocrinol. 6, 605u00e2 $ "617 (2018 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Heerspink, H. J. L. et cetera. Adjustment in albuminuria as a surrogate endpoint for development of kidney disease: a meta-analysis of procedure impacts in randomised professional tests. Lancet Diabetes Mellitus Endocrinol. 7, 128u00e2 $ "139 (2019 ). Articleu00c2.CASu00c2.Google Scholaru00c2.Mann, J. F. E. et al. Results of semaglutide along with as well as without concomitant SGLT2 prevention use in participants with style 2 diabetes mellitus and chronic kidney disease in the FLOW test. Nat. Med. https://doi.org/10.1038/s41591-024-03133-0 (2024 ). Neuen, B. L. et cetera. Cardiovascular, renal and safety end results with GLP-1 receptor agonists alone and in combo with SGLT2 preventions in style 2 diabetes mellitus: a systematic review and meta-analysis. Blood circulation https://doi.org/10.1161/CIRCULATIONAHA.124.071689 (2024 ). Apperloo, E. M. et al. Efficiency and security of SGLT2 preventions with and also without glucagon-like peptide 1 receptor agonists: a SMART-C joint meta-analysis of randomised regulated trials. Lancet Diabetic Issues Endocrinol. 12, 545u00e2 $ "557 (2024 ). Articleu00c2.CASu00c2.Google Scholaru00c2.Heerspink, H. J. L. et cetera. Impacts of tirzepatide versus blood insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 test: post-hoc study of an open-label, randomised, period 3 test. Lancet Diabetes Endocrinol. 10, 774u00e2 $ "785 (2022 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Tuttle, K. R. et al. Body body weight and eGFR throughout dulaglutide therapy in kind 2 diabetes mellitus and also moderate-to-severe chronic kidney condition (AWARD-7). Diabetes Obes. Metab. 21, 1493u00e2 $ "1497 (2019 ). Articleu00c2.CASu00c2.Google Scholaru00c2.Heerspink, H. J. L. et al. Results of tirzepatide versus insulin glargine on cystatin c-based kidney function: a SURPASS-4 message hoc review. Diabetes Care 46, 1501u00e2 $ "1506 (2023 ). Articleu00c2.CASu00c2.PubMed Centralu00c2.Google.com Scholaru00c2.Diabetes Mellitus Care (American Diabetes mellitus Organization, accessed 1 September 2024) https://diabetesjournals.org/diabetes/issue/73/Supplement_1Li, K. et al. Results of bariatric surgical operation on kidney functionality in obese patients: a step-by-step analysis and meta study. PLoS ONE 11, e0163907 (2016 ). Articleu00c2.PubMed Centralu00c2.Google.com Scholaru00c2.Bilha, S. C. et al. The impacts of bariatric surgical operation on renal results: an organized examine as well as meta-analysis. Obes. Surg. 28, 3815u00e2 $ "3833 (2018 ). Articleu00c2.Google.com Scholaru00c2.Clerte, M. et cetera. The gauged glomerular filtration price (mGFR) prior to and 6 months after bariatric surgical operation: a fly research. Nephrol. Ther. Thirteen, 160u00e2 $ "167 (2017 ). Articleu00c2.Google.com Scholaru00c2.Fawaz, S. et al. Adiponectin lessens glomerular endothelial glycocalyx interruption and also repairs glomerular barrier feature in a computer mouse style of type 2 diabetes mellitus. Diabetic issues 73, 964u00e2 $ "976 (2024 ). Articleu00c2.CASu00c2.Google Scholaru00c2.Sasson, A. N. &amp Cherney, D. Z. Renal hyperfiltration pertaining to diabetic issues mellitus and obesity in individual disease. World J. Diabetes 3, 1u00e2 $ "6 (2012 ). Articleu00c2.PubMed Centralu00c2.Google.com Scholaru00c2.Chagnac, A. &amp Friedman, A. N. Measuring albuminuria in individuals with being overweight: difficulties of the urinary system albumin-creatinine proportion. Kidney Med. 6, 100804 (2024 ). Articleu00c2.PubMed Centralu00c2.Google Scholaru00c2.Wilding, J. P. H. et cetera. Once-weekly semaglutide in adults with obese or even being overweight. N. Engl. J. Med. 384, 989u00e2 $ "1002 (2021 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Levey, A. S. et cetera. An even more precise approach to determine glomerular filtering rate coming from cream creatinine: a brand-new prophecy formula. Alteration of Diet Plan in Kidney Disease Study Group. Ann. Intern. Med. 130, 461u00e2 $ "470 (1999 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Stevens, J. et al. UHPLC-MS/MS procedure for iohexol judgment in human EDTA as well as lithium-heparin plasma, human pee and in goat- and also pig EDTA plasma. Bioanalysis 12, 981u00e2 $ "990 (2020 ). Articleu00c2.CASu00c2.Google Scholaru00c2.Tuttle, K. R. et cetera. Efficacy as well as protection of aldosterone synthase inhibition with as well as without empagliflozin for severe kidney condition: a randomised, managed, phase 2 trial. Lancet 403, 379u00e2 $ "390 (2024 ). Articleu00c2.CASu00c2.Google Scholaru00c2.de Zeeuw, D. et al. Efficiency of a novel inhibitor of vascular bond protein-1 in reducing albuminuria in patients along with diabetic renal health condition (ALBUM): a randomised, placebo-controlled, period 2 trial. Lancet Diabetes Endocrinol. 6, 925u00e2 $ "933 (2018 ). Articleu00c2.Google.com Scholaru00c2.Heerspink, H. J. L. et cetera. Zibotentan in combo with dapagliflozin compared with dapagliflozin in people with constant renal health condition (ZENITH-CKD): a multicentre, randomised, active-controlled, phase 2b, clinical test. Lancet 402, 2004u00e2 $ "2017 (2023 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.Heerspink, H. J. L. et al. Effect of avenciguat on albuminuria in people along with CKD: two randomized placebo-controlled trials. J. Am. Soc. Nephrol. 25, 1227u00e2 $ "1239 (2024 ). Articleu00c2.Google.com Scholaru00c2.Heerspink, H. J. L. et al. Sparsentan in people with IgA nephropathy: a prespecified interim review from a randomised, double-blind, active-controlled scientific trial. Lancet 401, 1584u00e2 $ "1594 (2023 ). Articleu00c2.CASu00c2.Google.com Scholaru00c2.